Differentiation of CD4+ Th cells is critical for immunity to malaria. Several innate immune
signaling pathways have been implicated in the detection of blood-stage Plasmodium …

Type I IFN signaling suppresses splenic T helper 1 (Th1) responses during blood‐stage
Plasmodium berghei ANKA (PbA) infection in mice, and is crucial for mediating tissue …

CD4 T cell-dependent antibody responses are essential for limiting Plasmodium parasite
replication and the severity of malaria; however, the factors that regulate humoral immunity …

During blood‐stage Plasmodium infection, large‐scale invasion of RBCs often occurs before
the generation of cellular immune responses. In Plasmodium berghei ANKA (PbA)‐infected …

CD4 T cells are required to fight malaria infection by promoting both phagocytic activity and
B cell responses for parasite clearance. In Plasmodium chabaudi infection, one specific CD4 …

Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite
burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms …

Many pathogens, including viruses, bacteria, and protozoan parasites, suppress cellular
immune responses through activation of type I IFN signaling. Recent evidence suggests that …

Humoral immunity is a critical effector arm for protection against malaria but develops only
slowly after repeated infections. T cell-mediated regulatory dynamics affect the development …

Plasmodium falciparum infection and malaria remain a risk for millions of children and
pregnant women. Here, we seek to integrate knowledge of mouse and human T helper cell …

The mechanism by which protective immunity to Plasmodium is lost in the absence of
continued exposure to this parasite has yet to be fully elucidated. It has been recently shown …