DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …

The development of biological markers of aging has primarily focused on adult samples.
Epigenetic clocks are a promising tool for measuring biological age that show impressive …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

DNA methylation gradiently changes with age and is likely to be involved in aging-related
processes with subsequent phenotype changes and increased susceptibility to certain …

DNA methylation age (DNAm age;“epigenetic clock”) has recently been described as highly
correlated with chronological age. Several studies suggest that DNAm age reflects, at least …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …