CXCR3+ T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and …
G Bowyer, A Grobbelaar, T Rampling… - Frontiers in …, 2018 - frontiersin.org
A malaria vaccine strategy targeting multiple lifecycle stages may be required to achieve a
high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of …
high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of …
A delayed fractionated dose RTS, S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of
three doses of RTS, S/AS01 malaria vaccine given at one-month intervals was inferior to a …
three doses of RTS, S/AS01 malaria vaccine given at one-month intervals was inferior to a …
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …
immunology analyses and controlled human infection models to define the protective …
Distinct helper T cell type 1 and 2 responses associated with malaria protection and risk in RTS, S/AS01E vaccinees
G Moncunill, M Mpina, AJ Nhabomba… - Clinical Infectious …, 2017 - academic.oup.com
Abstract Background The RTS, S/AS01E malaria vaccine has moderate efficacy, lower in
infants than children. Current efforts to enhance RTS, S/AS01E efficacy would benefit from …
infants than children. Current efforts to enhance RTS, S/AS01E efficacy would benefit from …
Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
The majority of routinely given vaccines require two or three immunisations for full protective
efficacy. Single dose vaccination has long been considered a key solution to improving the …
efficacy. Single dose vaccination has long been considered a key solution to improving the …
Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors
Interactions between B cells and CD4+ T follicular helper (Tfh) cells are key determinants of
humoral responses. Using samples from clinical trials performed with the malaria vaccine …
humoral responses. Using samples from clinical trials performed with the malaria vaccine …
Safety and efficacy of novel malaria vaccine regimens of RTS, S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP
We assessed a combination multi-stage malaria vaccine schedule in which RTS, S/AS01B
was given concomitantly with viral vectors expressing multiple-epitope thrombospondin …
was given concomitantly with viral vectors expressing multiple-epitope thrombospondin …
Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2. 1/AS02A vaccine candidate
SF Graves, B Kouriba, I Diarra, M Daou, A Niangaly… - Vaccine, 2016 - Elsevier
Abstract Based on Plasmodium falciparum (Pf) apical membrane antigen 1 (AMA1) from
strain 3D7, the malaria vaccine candidate FMP2. 1/AS02 A showed strain-specific efficacy in …
strain 3D7, the malaria vaccine candidate FMP2. 1/AS02 A showed strain-specific efficacy in …
Combination of RTS, S and Pfs25-IMX313 induces a functional antibody response against malaria infection and transmission in mice
F Brod, K Miura, I Taylor, Y Li, A Marini… - Frontiers in …, 2018 - frontiersin.org
The last two decades saw a dramatic reduction in malaria incidence rates, but this decrease
has been stalling recently, indicating control measures are starting to fail. An effective …
has been stalling recently, indicating control measures are starting to fail. An effective …
Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates
The development of an efficacious Plasmodium falciparum malaria vaccine remains a top
priority for global health. Vaccination with irradiated sporozoites is able to provide complete …
priority for global health. Vaccination with irradiated sporozoites is able to provide complete …