Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Despite decades of research and recent clinical trials, an efficacious long‐lasting
preventative vaccine for malaria remains elusive. This parasite infects mammals via …

Despite decades of research, malaria remains a global health crisis. Current subunit vaccine
approaches do not provide efficient long-term, sterilizing immunity against Plasmodium …

Malaria is a major global health problem, with severe mortality in children living in sub-
Saharan Africa, and there is currently no licensed, effective vaccine. However, vaccine …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

Tissue-resident memory CD8+ T (Trm) cells in the liver are critical for long-term protection
against pre-erythrocytic Plasmodium infection. Such protection can usually be induced with …

Vaccines that comprise attenuated viral vectors encoding antigens from target pathogens
generate potent T‐cell responses. One such pathogen is malaria, and in particular the liver …

Parasitic protozoa cause considerable disease in humans and, due to their intracellular life
cycle, induce robust CD8+ T cell responses. A greater understanding of the factors that …