Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue

T Afsar, S Razak, A Almajwal, MR Khan - BMC complementary and …, 2018 - Springer
Background Cisplatin (CP) drug is platinum compounds used for the treatment of various
human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia …

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

T Afsar, S Razak, A Almajwal, M Shabbir… - BMC complementary and …, 2019 - Springer
Background Increase oxidative trauma is the main cause behind Cisplatin (CP) induced
cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia …

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

T Afsar, S Razak, A Almajwal… - BMC complementary and …, 2017 - Springer
Background Cisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid
tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses …

In vitro protection of biological macromolecules against oxidative stress and in vivo toxicity evaluation of Acacia nilotica (L.) and ethyl gallate in rats

S Mohan, K Thiagarajan, R Chandrasekaran… - BMC complementary and …, 2014 - Springer
Background Recently, enormous research has been focused on natural bioactive
compounds possessing potential antioxidant and anticancer properties using cell lines and …

Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats

T Afsar, S Razak, KM Batoo, MR Khan - BMC complementary and …, 2017 - Springer
Background The use of doxorubicin (DOX) an anthracycline antineoplastic agent is
withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the …

Acacia hydaspica R. Parker ethyl-acetate extract abrogates cisplatin-induced nephrotoxicity by targeting ROS and inflammatory cytokines

T Afsar, S Razak, D Aldisi, M Shabbir, A Almajwal… - Scientific Reports, 2021 - nature.com
Cisplatin (CisPT) is a chemotherapeutic drug that outcomes in adverse effects. In this study,
we examined the effect of A. hydaspica ethyl acetate extract (AHE) in an animal model of …

Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats

T Afsar, S Razak, A Almajwal - Lipids in Health and Disease, 2019 - Springer
Background Doxorubicin (DOX) is an anthracycline agent mostly prescribed for various
cancers. However, its treatment is contiguous with toxic effects. Acacia hydaspica prevented …

Effects of Carissa opaca fruits extracts on oxidative pulmonary damages and fibrosis in rats

S Sahreen, MR Khan, RA Khan - BMC Complementary and Alternative …, 2014 - Springer
Background Carissa opaca is a Pakistani fruit, traditionally used in the treatment of various
human ailments including asthma and pulmonary damage. The present study investigated …

Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu

A Patil, M Modak - Medicines, 2017 - mdpi.com
Background: Plant-derived bioactive compounds are becoming immensely important as
potential drugs. Different solvents are being used for extraction of these phytochemicals …

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

A Shahid, R Ali, N Ali, S Kazim Hasan… - Environmental …, 2017 - Wiley Online Library
Abstract Benzo (a) pyrene [B (a) P] is a well‐known carcinogen present in the environment.
In this study, we evaluated the protective potential of methanolic bark extract of Acacia …