The main inconvenience of conventional eye drops is the rapid washout of the drugs due to
nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be …

Introduction: A major problem in ocular therapeutics with classical formulations is the
maintenance of an effective drug concentration at the site of action for a long period of time …

This paper presents an overview of the potential of chitosan‐based systems for improving
the retention and biodistribution of drugs applied topically onto the eye. Besides its low …

Most of the people in the world are affected by glaucoma, which leads to irreversible
blindness. Several patient friendly treatments are available, nevertheless medications lack …

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

The eye is a very important, yet sensitive organ, presenting complex anatomy. To overcome
its protective mechanisms, with the aim of improving drug delivery, drug encapsulation in …

From the past few decades, tremendous awareness has been laid on the use of natural
polymers in ocular drug delivery. Chitosan, a modified natural carbohydrate polymer, has …

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …

Nanoscience and nanotechnology has caused important breakthroughs in different
therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led …

Over the last years, the scientific interest about topical ocular delivery targeting the posterior
segment of the eye has been increasing. This is probably due to the fact that this is a non …