The ovarian hormones estrogen and progesterone are master regulators of the development
and function of a broad spectrum of human tissues, including the breast, reproductive and …

Steroid hormones, in particular estrogen and progesterone, play important roles in normal
and neoplastic breast development. Alterations in both estrogen signaling and progesterone …

Progesterone is considered as the pregnancy hormone and acts on many different target
tissues. Progesterone receptor (PR) signaling is important for normal development and the …

The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …

Understanding the biology of the breast and how ovarian hormones impinge on it is key to
rational new approaches in breast cancer prevention and therapy. Because of the success …

Progesterone and estradiol, and their nuclear receptors, play essential roles in the
physiology of the reproductive tract, the mammary gland and the nervous system. Estrogens …

Progesterone, the ovarian steroid hormone, regulates a plentitude of biological processes in
tissues ranging from the brain to bones. Recognizing the role of progesterone and its …

Hormonal therapy, such as estrogen-targeting therapy, has undergone remarkable
development in recent several years, using drugs such as LH–RH agonists, new SERMs …

Worldwide, breast cancer incidence has been increasing for decades. Exposure to
reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk …

At present, there is an extensive body of literature documenting the participation of estrogen
receptors (ER) and progesterone receptors (PR) in mammary gene expression. Yet, the …