Malaria remains a major public health burden despite approval for implementation of a
partially effective pre-erythrocytic malaria vaccine. There is an urgent need to accelerate …

Background Individuals living in endemic areas acquire immunity to malaria following
repeated parasite exposure. We sought to assess the controlled human malaria infection …

Background: The timing of infection is closely determined in controlled human malaria
infection (CHMI) studies, and as such they provide a unique opportunity to dissect changes …

Background: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate
vaccine and drug development. As CHMI trials are performed in a controlled environment …

BACKGROUND Naturally acquired immunity to malaria is incompletely understood. We
used controlled human malaria infection (CHMI) to study the impact of past exposure on …

To understand the effect of previous malaria exposure on antiparasite immune responses is
important for developing successful immunization strategies. Controlled human malaria …

Background A pre-erythrocytic vaccine could provide a useful tool for burden reduction and
eventual eradication of malaria. Mathematical malaria models provide a mechanism for …

Naturally acquired immunity to the blood-stage of the malaria parasite develops slowly in
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …

Introduction: Humoral immune responses play a pivotal role in naturally acquired immunity
to malaria. Understanding which humoral responses are impaired among individuals at …

Background Controlled human malaria infection (CHMI) studies, in which healthy volunteers
are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines …