Non-coding regions comprise most of the human genome and harbor a significant fraction of
risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We …

Modern genetic studies indicate that human brain evolution is driven primarily by changes in
gene regulation, which requires understanding the biological function of largely non-coding …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements
active during cortical neurogenesis. However, it remains poorly understood as to how these …

Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements …

To discover regulatory elements driving the specificity of gene expression in different cell
types and regions of the developing human brain, we generated an atlas of open chromatin …

Transcriptome analysis of human brain provides fundamental insight into development and
disease, but it largely relies on existing annotation. We sequenced transcriptomes of 72 …

The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric
disorders are due to genetic defects affecting forebrain development, making it imperative to …