Infectious plasmodium sporozoites grown in vitro

AG Eappen, SL Hoffman - US Patent 9,878,026, 2018 - Google Patents
The application is directed to in-vitro-reared Plasmodium sporozoites of human host range
wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes …

Infectious plasmodium sporozoites grown in vitro

AG Eappen, SL Hoffman - US Patent 10,441,646, 2019 - Google Patents
The application is directed to in vitro-reared Plasmodium sporozoites of human host range
wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes …

Purified plasmodium and vaccine compositions

BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 10,272,146, 2019 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of
Plasmodium sporozoites substantially separated from attendant non-sporozoite material …

Purified Plasmodium and vaccine composition

BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 8,821,896, 2014 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of
Plasmodium sporozoites Substantially separated from attendant non-sporozoite material …

Purified Plasmodium and vaccine composition

BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 8,992,944, 2015 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of
Plasmodium sporozoites Substantially separated from attendant non-sporozoite material …

Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production

SL Hoffman, TC Luke - US Patent 8,802,919, 2014 - Google Patents
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in
haematophagous insects generally, and production of Plasmodium species sporozoites in …

Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production

SL Hoffman, TC Luke - US Patent 7,229,627, 2007 - Google Patents
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in
hematophagous insects gen erally, and production of Plasmodium species sporozoites in …

Methods for the prevention of malaria

S Hoffman, T Luke - US Patent App. 11/133,963, 2005 - Google Patents
The invention comprises novel compositions and methods for protecting Subjects against
malaria. The compositions of the invention include aseptic, live attenuated Plasmodium …

Mosquito salivary gland extraction device and methods of use

RH Taylor, A Canezin, M Schrum, I Iordachita… - US Patent …, 2020 - Google Patents
A device and method of use for augmenting the extraction of salivary glands from
Plasmodium-infected mosquitoes, where the sporozoite stage of Plasmodium primarily …

Genetic attenuation of Plasmodium by B9 gene disruption

CJ Janse, T Annoura, B VAN SCHAIJK… - US Patent …, 2017 - Google Patents
Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated
(GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently …