The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes …
BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 10,272,146, 2019 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material …
BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 8,821,896, 2014 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites Substantially separated from attendant non-sporozoite material …
BKL Sim, M Li, RE Stafford, SL Hoffman - US Patent 8,992,944, 2015 - Google Patents
Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites Substantially separated from attendant non-sporozoite material …
SL Hoffman, TC Luke - US Patent 8,802,919, 2014 - Google Patents
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of Plasmodium species sporozoites in …
SL Hoffman, TC Luke - US Patent 7,229,627, 2007 - Google Patents
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in hematophagous insects gen erally, and production of Plasmodium species sporozoites in …
S Hoffman, T Luke - US Patent App. 11/133,963, 2005 - Google Patents
The invention comprises novel compositions and methods for protecting Subjects against malaria. The compositions of the invention include aseptic, live attenuated Plasmodium …
A device and method of use for augmenting the extraction of salivary glands from Plasmodium-infected mosquitoes, where the sporozoite stage of Plasmodium primarily …
CJ Janse, T Annoura, B VAN SCHAIJK… - US Patent …, 2017 - Google Patents
Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently …