In recent years, anti-tumor immunotherapy has shown promising results, and immune-
oncology is now emerging as the fourth major wave in the treatment of tumors after …

Epigenetic modifications, like histone acetylation, are essential for regulating gene
expression within cells. Cancer cells acquire pathological epigenetic modifications resulting …

HDAC inhibitors (HDACIs) are anticancer agents being developed in preclinical and clinical
settings due to their capacity to modulate gene expression involved in cell growth …

Background: With an increasing understanding of the antitumor immune response,
considerable progress has been made in the field of tumor immunotherapy in the last …

Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors
(HDACis) have positioned these agents as promising drug candidates in combatting cancer …

Understanding the contribution of dysregulated gene silencing to epigenomic alterations in
cancer development provides the rationale for the use of epigenetic modulators, such as …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Epigenetic modifications of chromatin, such as histone acetylation, are involved in
repression of tumor antigens and multiple immune genes that are thought to facilitate tumor …

Bone marrow transplantation is regarded as the most effective immunotherapy for
hematologic cancer, but it generally faces difficulties in matching. Aberrant expression of …

Acetylation of lysine residues acts to modify the function of a wide range of proteins. In
histones, it affects chromatin structure, which can impact gene transcription, whereas …