P Zimmermann, T Brückl, A Nocon… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the …
S Rao, Y Yao, J Ryan, T Li, D Wang, C Zheng, Y Xu… - Scientific reports, 2016 - nature.com
Previous studies have investigated the association between common variants in FKBP5 and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta …
FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid receptor. Polymorphisms at the FKBP5 locus have been associated with increased …
D Mehta, M Gonik, T Klengel… - Archives of general …, 2011 - jamanetwork.com
Context Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co- chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an …
Background Twin studies have demonstrated that both genetic and environmental factors influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …
Context In addition to trauma exposure, other factors contribute to risk for development of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors …
M Ising, AM Depping, A Siebertz… - European Journal of …, 2008 - Wiley Online Library
Mood and anxiety disorders are considered stress‐related diseases characterized by an impaired function of mineralocorticoid and glucocorticoid receptors (MR and GR …
BA Kohrt, CM Worthman, KJ Ressler… - International review of …, 2015 - Taylor & Francis
Despite increased attention to global mental health, psychiatric genetic research has been dominated by studies in high-income countries, especially with populations of European …
C Lavebratt, E Åberg, LK Sjöholm, Y Forsell - Journal of affective disorders, 2010 - Elsevier
BACKGROUND: Genetic variations in FKBP5, BDNF, P2RX7 and CACNA1 are current candidates for involvement in depression. METHODS: The single nucleotide polymorphisms …