Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Background Controlled human malaria infection (CHMI) studies, in which healthy volunteers
are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines …

The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …

Malaria draws global attention in a cyclic manner, with interest and associated financing
waxing and waning according to political and humanitarian concerns. Currently we are on …

Early clinical investigations of candidate malaria vaccines and antimalarial medications
increasingly employ an established model of controlled human malaria infection (CHMI) …

Modern controlled human malaria infection (CHMI) clinical trials have almost entirely
focussed on Plasmodium falciparum, providing a highly informative means to investigate …

Malaria is a disease of public health importance in many parts of the world. Currently, there
is no effective way to eradicate malaria, so developing safe, efficient, and cost‐effective …

Although there has been major recent progress in malaria vaccine development, substantial
challenges remain for achieving highly efficacious and durable vaccines against …

Abstract Background Since 1986, investigators at Walter Reed Army Institute of Research
(WRAIR) have been using controlled human malaria challenge (CHMI) in malaria-naive …

Malaria remains one of the world's worst health problems with 1.5 to 2.7 million deaths
annually; these deaths are primarily among children under 5 years of age and pregnant …