Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses

S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …

Induction of type 2 T helper cell allergen tolerance by IL-10–differentiated regulatory dendritic cells

X Li, A Yang, H Huang, X Zhang, J Town… - American journal of …, 2010 - atsjournals.org
In mouse models of asthma, therapeutic use of allergen-presenting IL-10–differentiated
dendritic cells (DCs) can abrogate airway hyperresponsiveness, and reduce other asthma …

Inhibition of human allergic T-cell responses by IL-10–treated dendritic cells: Differences from hydrocortisone-treated dendritic cells

I Bellinghausen, U Brand, K Steinbrink, AH Enk… - Journal of allergy and …, 2001 - Elsevier
Background: Dendritic cells (DCs) are able to induce human allergic TH1 responses as well
as TH2 responses. Objective: In this study, we examined the effect of antiinflammatory …

TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program

S Chamorro, JJ García-Vallejo, WWJ Unger… - The Journal of …, 2009 - journals.aai.org
Tolerogenic dendritic cells (TDC) offer a promising therapeutic potential to ameliorate
autoimmune diseases. Reported to inhibit adaptive immune responses, little is known about …

Dendritic cell‐derived IL‐15 controls the induction of CD8 T cell immune responses

R Rückert, K Brandt, E Bulanova… - European journal of …, 2003 - Wiley Online Library
The development and the differentiation of CD8+ T cells are dependent on IL‐15. Here, we
have studied the source and mechanism of how IL‐15 modulates CD8+ T cell‐mediated …

[HTML][HTML] Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity

F Granucci, I Zanoni, S Feau… - The EMBO …, 2003 - embopress.org
Dendritic cells are professional antigen‐presenting cells able to initiate innate and adaptive
immune responses against invading pathogens. In response to external stimuli dendritic …

Role of IL-6 in dendritic cell functions

YD Xu, M Cheng, PP Shang… - Journal of Leukocyte …, 2022 - academic.oup.com
Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the
innate and adaptive immune systems. These cells are broadly involved in cellular and …

Dendritic Cells—A Conductor of T Cell Differentiation—

N Kadowaki - Allergology International, 2007 - Elsevier
Induction of different types of adaptive immune responses depending on the nature of
antigens and the environmental context is crucial to cope with a variety of pathogens and …

Interleukin-2 production by dendritic cells and its immuno-regulatory functions

T Zelante, J Fric, AYW Wong… - Frontiers in …, 2012 - frontiersin.org
Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial
products and prime adaptive immune responses against pathogens. Furthermore, DCs also …

CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation

MJ Thomas, A Noble, E Sawicka… - The Journal of …, 2002 - journals.aai.org
Th1 and Th2 cells are counterinhibitory; their balance determines allergic sensitization. We
show here that CD8 T cell subsets break these rules as both T cytotoxic (Tc) 1 and Tc2 cells …