Navigating the immuno-epidemiology of malaria: Potential metrics for surveillance and cluster randomised trials
L Wu - 2018 - researchonline.lshtm.ac.uk
As malaria endemic countries progress towards elimination, accurately measuring
community-level transmission is critical for monitoring control strategies and the design of …
community-level transmission is critical for monitoring control strategies and the design of …
Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across …
Background As malaria transmission declines, sensitive diagnostics are needed to evaluate
interventions and monitor transmission. Serological assays measuring malaria antibody …
interventions and monitor transmission. Serological assays measuring malaria antibody …
Serological evaluation of the effectiveness of reactive focal mass drug administration and reactive vector control to reduce malaria transmission in Zambezi Region …
L Wu, MS Hsiang, LM Prach, L Schrubbe, H Ntuku… - …, 2022 - thelancet.com
Background Due to challenges in measuring changes in malaria at low transmission,
serology is increasingly being used to complement clinical and parasitological surveillance …
serology is increasingly being used to complement clinical and parasitological surveillance …
Serological evaluation of a cluster randomised trial on the use of reactive focal mass drug administration and reactive vector control to reduce malaria transmission in …
L Wu, MS Hsiang, LM Prach, L Schrubbe, H Ntuku… - medRxiv, 2021 - medrxiv.org
Due to challenges in measuring changes in malaria in low transmission settings, serology is
increasingly being used to complement clinical and parasitological surveillance …
increasingly being used to complement clinical and parasitological surveillance …
A longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzania
RA Simmons, L Mboera, ML Miranda, A Morris… - Malaria journal, 2017 - Springer
Background Measurements of anti-malarial antibodies are increasingly used as a proxy of
transmission intensity. Most serological surveys are based on the use of cross-sectional data …
transmission intensity. Most serological surveys are based on the use of cross-sectional data …
Distinct antibody signatures associated with different malaria transmission intensities in Zambia and Zimbabwe
Antibodies to Plasmodium falciparum are specific biomarkers that can be used to monitor
parasite exposure over broader time frames than microscopy, rapid diagnostic tests, or …
parasite exposure over broader time frames than microscopy, rapid diagnostic tests, or …
Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting
Background Coordinated scaled-up malaria control interventions have substantially
contributed to the dramatic decrease of malaria-related morbidity and mortality in several …
contributed to the dramatic decrease of malaria-related morbidity and mortality in several …
[HTML][HTML] Biosignatures of exposure/transmission and immunity
A blood test that captures cumulative exposure over time and assesses levels of naturally
acquired immunity (NAI) would provide a critical tool to monitor the impact of interventions to …
acquired immunity (NAI) would provide a critical tool to monitor the impact of interventions to …
[HTML][HTML] Analytical approaches for antimalarial antibody responses to confirm historical and recent malaria transmission: an example from the Philippines
MLM Macalinao, KM Fornace, RA Reyes… - The Lancet Regional …, 2023 - thelancet.com
Background Assessing the status of malaria transmission in endemic areas becomes
increasingly challenging as countries approach elimination. Serology can provide robust …
increasingly challenging as countries approach elimination. Serology can provide robust …
[HTML][HTML] Optimisation and standardisation of a multiplex immunoassay of diverse Plasmodium falciparum antigens to assess changes in malaria transmission using …
Background: Antibody responses have been used to characterise transmission and
exposure history in malaria-endemic settings for over a decade. Such studies have typically …
exposure history in malaria-endemic settings for over a decade. Such studies have typically …