A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study

Z Liu, PL Kuo, S Horvath, E Crimmins, L Ferrucci… - PLoS …, 2018 - journals.plos.org
Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …

Quest for a summary measure of biological age: the health and retirement study

EM Crimmins, B Thyagarajan, JK Kim, D Weir, J Faul - Geroscience, 2021 - Springer
Measures of biological age and its components have been shown to provide important
information about individual health and prospective change in health as there is clear value …

Multi-omic biological age estimation and its correlation with wellness and disease phenotypes: a longitudinal study of 3,558 individuals

JC Earls, N Rappaport, L Heath… - The Journals of …, 2019 - academic.oup.com
Biological age (BA), derived from molecular and physiological measurements, has been
proposed to better predict mortality and disease than chronological age (CA). In the present …

Association of blood chemistry quantifications of biological aging with disability and mortality in older adults

DC Parker, BN Bartlett, HJ Cohen… - The Journals of …, 2020 - academic.oup.com
Quantification of biological aging has been proposed for population surveillance of age-
related decline in system integrity and evaluation of geroprotective therapies. However …

Biomarkers related to aging in human populations

E Crimmins, S Vasunilashorn, JK Kim… - Advances in clinical …, 2008 - Elsevier
Biomarkers are increasingly employed in empirical studies of human populations to
understand physiological processes that change with age, diseases whose onset appears …

Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study

Z Liu, X Chen, TM Gill, C Ma, EM Crimmins… - PLoS …, 2019 - journals.plos.org
Background An individual's rate of aging directly influences his/her susceptibility to morbidity
and mortality. Thus, quantifying aging and disentangling how various factors coalesce to …

Development and validation of 2 composite aging measures using routine clinical biomarkers in the Chinese population: analyses from 2 prospective cohort studies

Z Liu - The Journals of Gerontology: Series A, 2021 - academic.oup.com
Background This study aimed to:(i) develop 2 composite aging measures in the Chinese
population using 2 recent advanced algorithms (the Klemera and Doubal method and …

[HTML][HTML] Molecular and phenotypic biomarkers of aging

X Xia, W Chen, J McDermott, JDJ Han - F1000Research, 2017 - ncbi.nlm.nih.gov
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

A biomarker-based biological age in UK Biobank: composition and prediction of mortality and hospital admissions

MS Chan, M Arnold, A Offer, I Hammami… - The Journals of …, 2021 - academic.oup.com
Background Chronological age is the strongest risk factor for most chronic diseases.
Developing a biomarker-based age and understanding its most important contributing …

Epigenetic and metabolomic biomarkers for biological age: a comparative analysis of mortality and frailty risk

LM Kuiper, HA Polinder-Bos, D Bizzarri… - The Journals of …, 2023 - academic.oup.com
Biological age captures a person's age-related risk of unfavorable outcomes using
biophysiological information. Multivariate biological age measures include frailty scores and …