Objective: Major depressive disorder is associated with an increased risk of mortality and
aging-related diseases. The authors examined whether major depression is associated with …

Clinical studies find that childhood adversity and stress-ful life events in adulthood increase
the risk for major depression and for suicide. The predispositions to either major depression …

Importance Depressive disorders arise from a combination of genetic and environmental risk
factors. Epigenetic disruption provides a plausible mechanism through which gene …

Objective Recently developed indices of cellular age based on DNA methylation (DNAm)
data, referred to as DNAm age, are being used to study factors that influence the rate of …

Aberrant DNA methylation in the blood of patients with major depressive disorder (MDD) has
been reported in several previous studies. However, no comprehensive studies using …

Background and Objectives DNA methylation algorithms are increasingly used to estimate
biological aging; however, how these proposed measures of whole-organism biological …

Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

Antidepressant medications are the most common treatment for major depression and
related disorders. Pharmacogenetic studies have demonstrated that response to these …

Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of
the disease burden because this course is most prevalent and typically requires long-term …

Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …