The liposome-based adjuvant system AS01 is under evaluation for use in several vaccines
in clinical development. We have shown previously that AS01 injected with hepatitis B …

The liposome-based adjuvant AS01 incorporates two immune stimulants, 3-O-desacyl-4′-
monophosphoryl lipid A and the saponin QS-21. AS01 is under investigation for use in …

Vaccine adjuvants such as alum and the oil-in-water emulsion MF59 are used to enhance
immune responses towards pure soluble antigens, but their mechanism of action is still …

Ag delivery to specific APCs is an attractive approach in developing strategies for
vaccination. CD169+ macrophages in the marginal zone of the spleen represent a suitable …

Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants
in licensed vaccines, yet their mechanisms are not fully known. Here we report that induction …

The degree of antigen adsorption to adjuvants in subunit vaccines may significantly
influence the immune responses they induce upon vaccination. Commonly used …

Vaccine formulations incorporating innate immune stimulants are highly immunogenic;
however, the biological signals that originate in the peripheral tissues at the site of injection …

After vaccination, innate cell populations transport antigen from the tissue, via the afferent
lymphatic vessels, into the local lymph node where they provide critical signals for the …

Saponins represent a promising class of vaccine adjuvant. Together with the TLR4-ligand
MPL, QS-21 is part of the Adjuvant System AS01, a key component of the malaria and zoster …

Cancer vaccines aim to efficiently prime cytotoxic CD8+ T cell responses which can be
achieved by vaccine targeting to dendritic cells. CD169+ macrophages have been shown to …