The jujubosides are saponin natural products reported to have immunoadjuvant, anticancer,
antibacterial, antifungal, and antisweet activities. The triterpene component, jujubogenin …

Herein, we detail a synthetic strategy toward the C/D rings of cucurbitacin I, a naturally
occurring triterpenoid. This route utilized ring-opening/ring-closing metathesis of a …

The first total synthesis of (±)-jujuyane, a cyclooctanoid natural product, was accomplished
from a (5+ 3) dimerization product of oxidopyrylium ylide that forms the cyclooctanoid core …

The asymmetric de novo synthesis of a cucurbitane natural product, octanorcucurbitacin B,
has been accomplished. Cucurbitanes are a family of structurally complex triterpenoids that …

Leveraging on the orchestrated application of both Schmidt and Yu glycosylations, the first
total syntheses of the echinocystic acid saponins pithedulosides D and E, the two …

An innovative, concise synthesis of the aminocyclopentenediol fragment of queuosine is
reported. The synthesis is based on the stereocontrolled addition of a vinylGrignard· LiCl …

The efficient synthesis and antifungal exploration of (+)-yahazunol and related natural
products are described. Central to this strategy is the Barton decarboxylative coupling …

Ursolic acid and uvaol are naturally occurring triterpenoids that exhibit a broad spectrum of
pharmacological activities, including cytotoxicity. However, a primary challenge in the …

Following the elucidation of jujubosides A, and C and acetyljujuboside B, novel
protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B, were isolated …

Holostane glycosides are characteristic metabolites of sea cucumbers, which possess
various biological activities. Here, we report the synthesis of two representative congeners …