Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Depression is a condition characterized by pervasive sadness, irritability, or anhedonia,
along with additional symptoms affecting concentration, motivation, neurovegetative …

Objectives: Evidence suggests that childhood maltreatment may negatively affect not only
the lifetime risk of depression but also clinically relevant measures of depression, such as …

Background The course of depression is poorer in clinical settings than in the general
population. Several predictors have been studied and there is growing evidence that a …

Background There is ample evidence showing that childhood maltreatment (CM) is a risk
factor for the development of depression in adulthood. However, little is known about the …

Mental illnesses in later life are multidimensional phenomena that occur in interpersonal,
psychosocial, and biological contexts. With depression used as an example, the purpose of …

Background The episodic nature of major depressive disorder (MDD) in clinically referred
adults has been well-characterized, particularly by the NIMH Collaborative Depression …

BackgroundResearch on the long-term course of major depressive disorder (MDD) is
hindered by the absence of established course criteria and by idiosyncratic definitions of …

Major depressive disorder (MDD) is highly disabling and typically runs a recurrent course.
Knowledge about prevention of relapse and recurrence is crucial to the long-term welfare of …

Few reliable predictors indicate which depressed individuals respond to antidepressants.
Several studies suggest that a history of early-life trauma predicts poorer response to …