The complexity and diversity of major histocompatibility complex challenge disease association studies

ML Lokki, R Paakkanen - Hla, 2019 - Wiley Online Library
The major histocompatibility complex (MHC; 6p21. 3) contains the most polymorphic genes,
the most gene dense parts, and the highest diversity of functional gene clusters of the …

Imbalance of genes encoding natural killer immunoglobulin-like receptors and human leukocyte antigen in patients with biliary cancer

M Cornillet, H Jansson, M Schaffer, L Hertwig, L Berglin… - Gastroenterology, 2019 - Elsevier
Background & Aims Bile duct tumors are rare and have poor prognoses. Natural killer (NK)
cells are frequent in human liver and infiltrate these tumors but do not control their …

Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysis

FY Wang, CC Chi - Medicine, 2019 - journals.lww.com
Association of rosacea with inflammatory bowel disease: A MO... : Medicine Association of
rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysis : Medicine Log …

Integrative analysis of transcriptome‐wide association study data and messenger RNA expression profiles identified candidate genes and pathways for inflammatory …

B Cheng, X Liang, Y Wen, P Li, L Zhang… - Journal of cellular …, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a complex disease, resulting from abnormal immune
response to intestinal tract microbiota in genetically susceptible individuals. Crohn's disease …

Are we ready to include prognostic factors in inflammatory bowel disease trials?

CR Lindholm, CA Siegel - Current Pharmaceutical Design, 2019 - ingentaconnect.com
Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by
periodic episodes of flares and remission. Treatment is aimed at healing the bowel, to …

Multiple epistasis interactions within MHC are associated with ulcerative colitis

J Zhang, Z Wei, CJ Cardinale, ES Gusareva… - Frontiers in …, 2019 - frontiersin.org
Successful searching for epistasis is much challenging, which generally requires very large
sample sizes and/or very dense marker information. We exploited the largest Crohn's …

Impact of red meat, processed meat and fibre intake on risk of late-onset chronic inflammatory diseases: Prospective cohort study on lifestyle factors using the Danish ' …

NF Rasmussen, KH Rubin, M Stougaard… - BMJ open, 2019 - bmjopen.bmj.com
Introduction Chronic inflammatory diseases (CIDs)(Crohn's disease, ulcerative colitis,
psoriasis, psoriatic arthritis, rheumatoid arthritis and multiple sclerosis) are diseases of the …

Inflammatory Bowel Disease (IBD)—A textbook case for multi-centric banking of human biological materials

I Cleynen, L Linsen, S Verstockt, B Verstockt… - Frontiers in …, 2019 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition affecting
mainly the gastro-intestinal tract with two main entities: Crohn's disease (CD) and ulcerative …

Functional rare variants influence the clinical response to anti-TNF therapy in Crohn's disease

M Chaparro, A Aterido, I Guerra… - Therapeutic …, 2019 - journals.sagepub.com
Background: The effect of low-frequency functional variation on anti-tumor necrosis factor
alpha (TNF) response in Crohn's disease (CD) patients remains unexplored. The objective …

IBD genomic risk loci and overlap with other inflammatory diseases

F Hadizadeh, CW Lees, C Labbé, JD Rioux… - Molecular Genetics of …, 2019 - Springer
Although it has been known for decades that susceptibility to inflammatory bowel disease
(IBD) and its major subtypes is partly inherited, significant progress has been made in …