Maturation of the human cerebral cortex during adolescence: myelin or dendritic arbor?
Previous in vivo studies revealed robust age-related variations in structural properties of the
human cerebral cortex during adolescence. Neurobiology underlying these maturational …
human cerebral cortex during adolescence. Neurobiology underlying these maturational …
Proteomic atlas of the human brain in Alzheimer's disease
J McKetney, RM Runde, AS Hebert… - Journal of proteome …, 2019 - ACS Publications
The brain represents one of the most divergent and critical organs in the human body. Yet, it
can be afflicted by a variety of neurodegenerative diseases specifically linked to aging …
can be afflicted by a variety of neurodegenerative diseases specifically linked to aging …
[HTML][HTML] Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders
Transcriptional regulatory changes in the developing and adult brain are prominent features
of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly …
of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly …
[HTML][HTML] KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
L Hinz, J Torrella Barrufet, VM Heine - Acta neuropathologica …, 2019 - Springer
Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl
CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression …
CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression …
[HTML][HTML] Three-way clustering of multi-tissue multi-individual gene expression data using semi-nonnegative tensor decomposition
M Wang, J Fischer, YS Song - The annals of applied statistics, 2019 - ncbi.nlm.nih.gov
The advent of high-throughput sequencing technologies has led to an increasing availability
of large multi-tissue data sets which contain gene expression measurements across different …
of large multi-tissue data sets which contain gene expression measurements across different …
Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical …
Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a
broad range of disorders and are closely tied to cortical-striatal-thalamic-cortical function …
broad range of disorders and are closely tied to cortical-striatal-thalamic-cortical function …
Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus
Z Mirzadeh, KM Alonge, E Cabrales… - Nature …, 2019 - nature.com
In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal
development of neurocircuits in the hypothalamic arcuate nucleus (ARC), a critical brain …
development of neurocircuits in the hypothalamic arcuate nucleus (ARC), a critical brain …
[HTML][HTML] Building an asymmetrical brain: The molecular perspective
The brain is one of the most prominent examples for structural and functional differences
between the left and right half of the body. For handedness and language lateralization, the …
between the left and right half of the body. For handedness and language lateralization, the …
The architecture of mammalian cortical connectomes in light of the theory of the dual origin of the cerebral cortex
Uncovering organizational principles of the cerebral cortex is essential for proper
understanding of this prominent structure of the mammalian brain. The theory of the dual …
understanding of this prominent structure of the mammalian brain. The theory of the dual …
Topological gene expression networks recapitulate brain anatomy and function
Understanding how gene expression translates to and affects human behavior is one of the
ultimate goals of neuroscience. In this paper, we present a pipeline based on Mapper, a …
ultimate goals of neuroscience. In this paper, we present a pipeline based on Mapper, a …