Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually
asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of …

Introduction Ebola virus (EBOV) is an RNA virus of the Filoviridae family that is responsible
for outbreaks of hemorrhagic fevers in primates with a lethality rate as high as 90%. EBOV …

Background Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T
cells is often observed in lethal infections. We have previously shown that EBOV VP40 in …

Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of
causing severe hemorrhagic fever with up to 80–90% mortality rates. The most recent …

Ebola virus (EBOV) can cause a devastating hemorrhagic disease, leading to death in a
short period of time. After infection, the resulting EBOV disease results in high levels of …

Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a 'sepsis-
like'syndrome and lymphopenia despite T cells being resistant to Ebola infection. The …

Virus entry into host cells is the first step of infection and a crucial determinant of
pathogenicity. Here we show that Ebola virus-like particles (EBOV-VLPs) composed of the …

Ebola haemorrhagic fever causes deadly disease in humans and non-human primates
resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However …

Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The
ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into …

Highlights•Species-specific restrictions control EBOV cell entry.•EBOV-encoded proteins
block the type I IFN response in infected cells.•Most humans are immunologically naïve to …