Owing to safety concerns or insufficient efficacy, few drug candidates are approved for
marketing. Drugs already on the market may be withdrawn due to adverse effects (AEs) …

Motivation: Statins are the most widely used cholesterol-lowering drugs. The primary target
of statins is HMG-CoA reductase, a key enzyme in cholesterol synthesis. However, statins …

Recent pharmacological studies have been developed based on finding new disease-
related genes, accompanied by the production of gene-manipulated disease model animals …

Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic
cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and …

Genome-wide identification of all target proteins of drug candidate compounds is a
challenging issue in drug discovery. Moreover, emerging phenotypic effects, including …

Background Identification of functional non-coding variants and their mechanistic
interpretation is a major challenge of modern genomics, especially for precision medicine …

Side-effects are the unintended consequence of therapeutic treatments, but they can also be
seen as valuable read-outs of drug effects in humans; these effects are difficult to infer or …

Statins, also known as HMG-CoA reductase inhibitors, are one of the most potently
prescribed and thoroughly researched medications, predominantly utilized for managing …

In pharmacology, it is crucial to understand the complex biological responses that drugs
elicit in the human organism and how well they can be inferred from model organisms. We …

Statins are the most commonly prescribed class of drug worldwide and therapy is highly
effective in reducing low-density lipoprotein cholesterol levels and cardiovascular events …