Cellular crosstalk is essential for proper organogenesis. Although originally assumed to be
simple conduits for blood, endothelial cells (ECs) actively coordinate organ development …

The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then
throughout the embryo to establish circulatory networks that further acquire organ-specific …

The formation, growth and maintenance of our organs, such as our kidneys or pancreas,
requires their coordinated growth alongside the intricate vasculature that pervades them …

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

Early in 1865, the Swiss anatomist Wihelm His introduced a new concept of endothelium in
a programmatic assay and first defined the endothelium as the lining of the vasculature and …

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …

The kidney vasculature facilitates the excretion of wastes, the dissemination of hormones,
and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is …

Endothelial cells (ECs) form an extensive network of blood vessels that has numerous
essential functions in the vertebrate body. In addition to their well-established role as a …

Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …