Renal phosphate handling critically determines plasma phosphate and whole body
phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate …

Renal control of systemic phosphate homeostasis is critical as evident from inborn and
acquired diseases causing renal phosphate wasting. At least three transport proteins are …

The Na+-dependent phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in
kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with prominent …

Loss-of-function mutations of SLC34A3 represent an established cause of a distinct renal
phosphate wasting disorder termed hereditary hypophosphatemic rickets with hypercalciuria …

Regulation of phosphate homeostasis is critical for many biological processes, and both
hypophosphatemia and hyperphosphatemia can have adverse clinical consequences. Only …

The serum phosphorus level is maintained through a complex interplay between intestinal
absorption, exchange intracellular and bone storage pools, and renal tubular reabsorption …

The proximal renal epithelia express three different Na-dependent inorganic phosphate (Pi)
cotransporters: NaPi-IIa/SLC34A1, NaPi-IIc/SLC34A3, and PiT2/SLC20A2. Constitutive …

Inorganic phosphate (Pi) is an essential physiological compound, highlighted by the
syndromes caused by hypo or hyperphosphatemic states. Hyperphosphatemia is associated …

Abnormalities of the inorganic phosphate (Pi) reabsorption in the kidney result in various
metabolic disorders. Na+-dependent Pi (Na/Pi) transporters in the brush border membrane …

The present study describes two novel compound heterozygous mutations, c. 410C> T (p.
T137M)(T137M) on the maternal and g. 4225_50del on the paternal allele of SLC34A3, in a …