Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex

RN Kirchdoerfer, EO Saphire… - … Crystallographica Section F …, 2019 - journals.iucr.org
Ebola virus is an emerging virus that is capable of causing a deadly disease in humans.
Replication, transcription and packaging of the viral genome are carried out by the viral …

Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution

Y Sugita, H Matsunami, Y Kawaoka, T Noda, M Wolf - Nature, 2018 - nature.com
Ebola virus causes haemorrhagic fever with a high fatality rate in humans and non-human
primates. It belongs to the family Filoviridae in the order Mononegavirales, which are viruses …

Electron cryo-microscopy structure of Ebola virus nucleoprotein reveals a mechanism for nucleocapsid-like assembly

Z Su, C Wu, L Shi, P Luthra, GD Pintilie, B Johnson… - Cell, 2018 - cell.com
Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral
nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular …

In vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coli

R Peng, T Zhu, BO Oladejo, AM Musyoki, Y Cui… - Protein & …, 2016 - academic.oup.com
Ebola virus (EBOV) harbors an RNA genome encapsidated by nucleoprotein (NP) along
with other viral proteins to form a nucleocapsid complex. Previous Cryo-eletron tomography …

Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography

TAM Bharat, T Noda, JD Riches… - Proceedings of the …, 2012 - National Acad Sciences
Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic fever with high
mortality rates. It assembles heterogenous, filamentous, enveloped virus particles containing …

Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 Å resolution

S Dong, P Yang, G Li, B Liu, W Wang, X Liu, B Xia… - Protein & …, 2015 - academic.oup.com
Ebola virus (EBOV) is a key member of Filoviridae family and causes severe human
infectious diseases with high morbidity and mortality. As a typical negative-sense single …

Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses

LE Baker, JF Ellena, KB Handing… - … Section D: Structural …, 2016 - journals.iucr.org
The Filoviridae family of negative-sense, single-stranded RNA (ssRNA) viruses is comprised
of two species of Marburgvirus (MARV and RAVV) and five species of Ebolavirus, ie Zaire …

Characterization of the Ebola virus nucleoprotein–RNA complex

T Noda, K Hagiwara, H Sagara… - Journal of General …, 2010 - microbiologyresearch.org
When Ebola virus nucleoprotein (NP) is expressed in mammalian cells, it assembles into
helical structures. Here, the recombinant NP helix purified from cells expressing NP was …

Assembly of the Ebola virus nucleoprotein from a chaperoned VP35 complex

RN Kirchdoerfer, DM Abelson, S Li, MR Wood… - Cell reports, 2015 - cell.com
Ebolavirus NP oligomerizes into helical filaments found at the core of the virion,
encapsidates the viral RNA genome, and serves as a scaffold for additional viral proteins …

The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein

PJ Dziubańska, U Derewenda, JF Ellena… - … Section D: Biological …, 2014 - journals.iucr.org
Ebolavirus (EBOV) causes severe hemorrhagic fever with a mortality rate of up to 90%.
EBOV is a member of the order Mononegavirales and, like other viruses in this taxonomic …