Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes,
and cardiovascular disease. These diseases are associated with accumulation of lipids in …

Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease.
When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic …

Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Recent studies provide clues regarding the cellular mechanisms that determine whether
excess lipid accumulation is well tolerated or cytotoxic. Critical in this process are …

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to
the pathogenesis of the metabolic syndrome and heart disease. The term 'lipotoxicity'was …

Cardiovascular diseases account for approximately one third of all deaths globally. Obese
and diabetic patients have a high likelihood of dying from complications associated with …

Obesity is a well-known risk factor for the development of type 2 diabetes mellitus and
cardiovascular disease. Importantly, obesity is not only associated with lipid accumulation in …

Obesity and type 2 diabetes mellitus are the major noncommunicable public health problem
of the 21st century. The best strategy to tackle this problem is to develop strategies to …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …