Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma
multiforme (GBM) is a complicated pathological process with dysregulated methylation and …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Simple Summary Metabolic reprogramming in glioblastoma is a hallmark of malignancy.
Metabolic enzymes and metabolites participate in energetic metabolism and function as …

Glioblastoma (GBM), the most aggressive brain tumor, is associated with a median survival
at diagnosis of 16–20 months and limited treatment options. The key hallmark of GBM is …

Constitutively activated oncogenic signaling via genetic mutations such as in the
EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for …

Tumor metabolism is emerging as a potential target for cancer therapies. This new approach
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …

Dysregulation of metabolism allows tumor cells to generate needed building blocks as well
as to modulate epigenetic marks to support cancer initiation and progression. Cancer …

Epigenetic alterations contribute to tumor development, progression, and therapeutic
response. Many epigenetic enzymes use metabolic intermediates as cofactors to modify …

Simple Summary Cancer cells change their metabolism to support a chaotic and
uncontrolled growth. In addition to meeting the metabolic needs of the cell, these changes in …

Adaptation of cellular function with the nutrient environment is essential for survival. Failure
to adapt can lead to cell death and/or disease. Indeed, energy metabolism alterations are a …