Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm
PR Albert, B Le François, F Vahid-Ansari - Journal of psychiatry and …, 2019 - jpn.ca
Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity
PR Albert, LM Fiori - Current pharmaceutical design, 2014 - ingentaconnect.com
The etiology of major depression remains unclear, but reduced activity of the serotonin (5-
HT) system remains implicated and treatments that increase 5-HT neurotransmission can …
HT) system remains implicated and treatments that increase 5-HT neurotransmission can …
5-HT1A receptors, gene repression, and depression: guilt by association
PR Albert, S Lemonde - The Neuroscientist, 2004 - journals.sagepub.com
The serotonin system is implicated in major depression and suicide and is negatively
regulated by somatodendritic 5-HT1A autoreceptors. Desensitization of 5-HT1A …
regulated by somatodendritic 5-HT1A autoreceptors. Desensitization of 5-HT1A …
The 5-HT1B receptor: a novel target for the pathophysiology of depression (supplementary tables)
BM Ruf, Z Bhagwagar - Current drug targets, 2009 - ingentaconnect.com
The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …
Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site
B Le François, J Soo, AM Millar, M Daigle… - Neurobiology of …, 2015 - Elsevier
Abstract The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic
tone, is implicated in major depressive disorder (MDD) where it is often found to be dys …
tone, is implicated in major depressive disorder (MDD) where it is often found to be dys …
Variability in the 5-HT2A receptor gene is associated with seasonal pattern in major depression
The 102-T/C polymorphism of the 5-HT 2A receptor gene was analysed in 159 patients with
major depression and 164 unrelated and healthy controls using a case-control design …
major depression and 164 unrelated and healthy controls using a case-control design …
5-HT1A receptor function in major depressive disorder
J Savitz, I Lucki, WC Drevets - Progress in neurobiology, 2009 - Elsevier
Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …
Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
PR Albert - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
The serotonin-1A (5-HT1A) receptor is an abundant post-synaptic 5-HT receptor
(heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the …
(heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the …
[HTML][HTML] Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
PR Albert, B Le François - Frontiers in neuroscience, 2010 - frontiersin.org
Major depression is the most common form of mental illness, and is treated with
antidepressant compounds that increase serotonin (5-HT) neurotransmission. Increased 5 …
antidepressant compounds that increase serotonin (5-HT) neurotransmission. Increased 5 …
Genetics of serotonin receptors and depression: state of the art
C Fabbri, A Marsano, A Serretti - Current drug targets, 2013 - ingentaconnect.com
Major depression (MD) is a major health problem, partly due to the incomplete
understanding of the pathogenic mechanisms of the disease. Research efforts have mainly …
understanding of the pathogenic mechanisms of the disease. Research efforts have mainly …