Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic‐and GPR109a‐mediated mechanisms

RJF Felizardo, DC de Almeida, RL Pereira… - The FASEB …, 2019 - Wiley Online Library
Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible
carbohydrates by the gut microbiota. Butyrate contributes to gut homeostasis, but it may also …

The role and mechanism of butyrate in the prevention and treatment of diabetic kidney disease

X Cheng, T Zhou, Y He, Y Xie, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease
and is a major burden on the healthcare system. The current understanding of the …

Butyrate in energy metabolism: there is still more to learn

L Zhang, C Liu, Q Jiang, Y Yin - Trends in Endocrinology & Metabolism, 2021 - cell.com
Butyrate, a main product of gut microbial fermentation, has been recognized as an important
mediator of gut microbiota regulation in whole body energy homeostasis. However, the …

Therapeutic potential of butyrate for treatment of type 2 diabetes

T Arora, V Tremaroli - Frontiers in endocrinology, 2021 - frontiersin.org
Metagenomics studies have shown that type 2 diabetes (T2D) is associated with an altered
gut microbiota. Whereas different microbiota patterns have been observed in independent …

Butyrate properties in immune-related diseases: friend or foe?

M Anshory, RMRA Effendi, H Kalim, RF Dwiyana… - Fermentation, 2023 - mdpi.com
Butyrate is a short-chain fatty acid (SCFA) created within the intestinal lumen by bacterial
fermentation of largely undigested dietary carbohydrates. Its beneficial effects on cellular …

Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases

N Gasaly, MA Hermoso, M Gotteland - International journal of molecular …, 2021 - mdpi.com
This review describes current evidence supporting butyrate impact in the homeostatic
regulation of the digestive ecosystem in health and inflammatory bowel diseases (IBDs) …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

Is butyrate the link between diet, intestinal microbiota and obesity‐related metabolic diseases?

LK Brahe, A Astrup, LH Larsen - Obesity reviews, 2013 - Wiley Online Library
It is increasingly recognized that there is a connection between diet, intestinal microbiota,
intestinal barrier function and the low‐grade inflammation that characterizes the progression …

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

SC Bridgeman, W Northrop, PE Melton… - Pharmacological …, 2020 - Elsevier
Metabolic syndrome (MetS) and the associated incidence of cardiovascular disease and
type 2 diabetes represents a significant contributor to morbidity and mortality worldwide …

[HTML][HTML] Butyrate: a double-edged sword for health?

H Liu, J Wang, T He, S Becker, G Zhang, D Li, X Ma - Advances in nutrition, 2018 - Elsevier
Butyrate, a four-carbon short-chain fatty acid, is produced through microbial fermentation of
dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and …