Rett syndrome (RTT) is a human neurodevelopmental disorder, whose pathogenesis has
been linked to both oxidative stress and subclinical inflammatory status (OxInflammation) …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The
activation of inflammatory cells is crucial for the development of MS and is shown to induce …

Memory impairment is a feature of several diseases and detrimental as aging population
have increased worldwide. Sustained advanced glycation end products (AGEs) receptor …

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous
system (CNS). The immune response in MS patients leads to the infiltration of immune cells …

Introduction Diabetes mellitus (DM) is characterized by chronic hyperglycemia and diabetic
complications. Exacerbated cortical neuronal degeneration was observed in Alzheimer's …

Methylglyoxal (MG) is one of the most powerful glycating agents of proteins and other
important cellular components and has been shown to be toxic to cultured cells. Under …

Glucose is the main energy substrate for the brain. There is now extensive evidence
indicating that the metabolic profile of neural cells with regard to glucose utilization and …

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal
(MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis …

Glycation is implicated in neurological disorders. In some cases it plays a key role in the
pathogenesis, in others it plays a co-adjuvant role or it appears as a consequence of …

Methylglyoxal (MGO) is a major glycating agent that reacts with basic residues of proteins
and promotes the formation of advanced glycation end products (AGEs) which are believed …