Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Epidemiological and clinical studies have shown that children exposed to adverse
experiences are at increased risk for the development of depression, anxiety disorders, and …

Stressor exposure during early life has the potential to increase an individual's susceptibility
to a number of neuropsychiatric conditions such as mood and anxiety disorders and …

Childhood adversity can have life-long consequences for the response to stressful events
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …

This review focuses on current research developments in the study of gene by early life
stress (ELS) interactions and depression. ELS refers to aversive experiences during …

Background: A substantial body of experimental and epidemiological evidence has been
accumulated suggesting that stressful events in early life including acute perinatal stress …

The hypothalamic–pituitary–adrenal (HPA) axis is critically involved in the neuroendocrine
regulation of stress adaptation, and the restoration of homeostasis following stress …

Stress, particularly when experienced early in life, can have profound implications for mental
health. Previous research covering various tissues such as the brain, suggests that the …

In recent years, translational research involving humans and animals has uncovered
biological and physiological pathways that explain associations between early adverse …

Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …