Selenoproteins are a unique class of proteins that play key roles in redox signaling in the
brain. This unique organ is comprised of a wide variety of cell types that includes excitatory …

The essential trace element selenium, as selenocysteine, is incorporated into antioxidant
selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR) and …

Although dietary selenium (Se) deficiency results in phenotypes associated with
selenoprotein depletion in various organs, the brain is protected from Se loss. To address …

After the discovery of selenium (Se) as an essential trace element, direct evidence that Se
plays a role in brain function remained relatively scarce for many years. This was probably …

How is the essential micronutrient, selenium (Se), transported in the serum and then
donated to tissues? In this issue of the Biochemical Journal, Schweizer and colleagues …

Fifty years have passed since the discovery of the first selenoprotein by Rotruck and
colleagues. In that time, the essential nature of selenium has come to light including the …

Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a
potentially novel, possibly underestimated, and previously difficult to study role of selenium …

Selenoproteins are a distinct class of proteins that are characterized by the co-translational
incorporation of selenium (Se) in the form of the 21st amino acid selenocysteine …

Selenoprotein P (SELENOP1) is a selenium-rich antioxidant protein involved in extracellular
transport of selenium (Se). SELENOP1 also has metal binding properties. The trace element …

Genes of selenoproteome have been increasingly implicated in various aspects of
neurobiology and neurological disorders, but remain largely elusive in Parkinson's disease …