Cross-sectional and cumulative longitudinal central nervous system penetration effectiveness scores are not associated with neurocognitive impairment in a well …

GMA Santos, I Locatelli, M Métral… - Open forum …, 2019 - academic.oup.com
Background Neurocognitive impairment (NCI) in people with human immunodeficiency virus
(PWH) remains a concern despite potent antiretroviral therapy (ART). Higher central nervous …

Revised central nervous system neuropenetration-effectiveness score is associated with cognitive disorders in HIV-infected patients with controlled plasma viraemia

N Ciccarelli, M Fabbiani, M Colafigli… - Antiviral …, 2013 - journals.sagepub.com
Background The objective of our study was to compare two different central nervous system
penetration-effectiveness (CPE) scores for the prediction of cognitive dysfunction in HIV …

Central nervous system penetration‐effectiveness rank does not reliably predict neurocognitive impairment in HIV‐infected individuals

R Libertone, P Lorenzini, P Balestra… - Journal of the …, 2014 - Wiley Online Library
Introduction Central nervous system (CNS) penetration‐effectiveness (CPE) rank was
proposed in 2008 as an estimate of penetration of ARV regimen into the CNS, and validated …

[PDF][PDF] Persistent HIV in the central nervous system during treatment is associated with worse antiretroviral therapy penetration and cognitive impairment

S Letendre, D McClernon, RJ Ellis, J Muñoz-Moreno… - AIDS, 2009 - researchgate.net
Background: Cognitive impairment can occur or persist during antiretroviral therapy (ART).
Explanations include comorbidities, neurotoxic ART, persistent neuroinflammation, or …

[HTML][HTML] HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: a review of the literature examining the central nervous system …

A Arentoft, K Troxell, K Alvarez, M Aghvinian… - Viruses, 2022 - mdpi.com
This literature review summarizes the existing research examining the CNS penetration
effectiveness (CPE) score and neurocognitive outcomes (ie, neuropsychological …

The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study: baseline participant profile

M Metral, KEA Darling, I Locatelli, I Nadin… - HIV …, 2020 - Wiley Online Library
Objectives The aim of the study was to examine baseline neurocognitive impairment (NCI)
prevalence and factors associated with NCI among patients enrolled in the Neurocognitive …

Antiretroviral neuropenetration scores better correlate with cognitive performance of HIV-infected patients after accounting for drug susceptibility

M Fabbiani, P Grima, B Milanini, A Mondi… - Antiviral …, 2015 - journals.sagepub.com
Background The aim of the study was to explore how viral resistance and antiretroviral
central nervous system (CNS) penetration could impact on cognitive performance of HIV …

How helpful are the European AIDS Clinical Society cognitive screening questions in predicting cognitive impairment in an aging, well‐treated HIV‐positive population …

M Metral, I Nadin, I Locatelli, PE Tarr, A Calmy… - HIV …, 2020 - Wiley Online Library
Objectives Diagnosing neurocognitive impairment (NCI) in HIV infection requires time‐
consuming neuropsychological assessment. Screening tools are needed to identify when …

Can high central nervous system penetrating antiretroviral regimens protect against the onset of HIV-associated neurocognitive disorders?

M Vassallo, J Durant, V Biscay, C Lebrun-Frenay… - Aids, 2014 - journals.lww.com
Objective: To assess changes over time in neuropsychological test results (NPr) and risk
factors among a regularly followed HIV-infected patient population. Methods: Prospective …

Increased prevalence of neurocognitive impairment in aging people living with human immunodeficiency virus: the ANRS EP58 HAND 55–70 study

A Makinson, J Dubois… - Clinical Infectious …, 2020 - academic.oup.com
Background There are limited data on the comparative prevalence of neurocognitive
impairment (NCI) in aging people living with human immunodeficiency virus (PLHIV) and …