An investigation of interpretable deep learning for adverse drug event prediction

J Rebane, I Karlsson… - 2019 IEEE 32nd …, 2019 - ieeexplore.ieee.org
A variety of deep learning architectures have been developed for the goal of predictive
modelling in regards to detecting health diagnoses in medical records. Several models have …

Exploiting complex medical data with interpretable deep learning for adverse drug event prediction

J Rebane, I Samsten, P Papapetrou - Artificial Intelligence in Medicine, 2020 - Elsevier
A variety of deep learning architectures have been developed for the goal of predictive
modelling and knowledge extraction from medical records. Several models have placed …

Explainable predictions of adverse drug events from electronic health records via oracle coaching

L Crielaard, P Papapetrou - 2018 IEEE International …, 2018 - ieeexplore.ieee.org
Information about drug efficacy and safety is limited despite current research on adverse
drug events (ADEs). Electronic health records (EHRs) may be an overcoming medium …

Machine-learning-based adverse drug event prediction from observational health data: A review

J Denck, E Ozkirimli, K Wang - Drug Discovery Today, 2023 - Elsevier
Adverse drug events (ADEs) are responsible for a significant number of hospital admissions
and fatalities. Machine learning models have been developed to assess individual patient …

Predictive modeling of structured electronic health records for adverse drug event detection

J Zhao, A Henriksson, L Asker, H Boström - BMC medical informatics and …, 2015 - Springer
Background The digitization of healthcare data, resulting from the increasingly widespread
adoption of electronic health records, has greatly facilitated its analysis by computational …

Assessing the clinical validity of attention-based and SHAP temporal explanations for adverse drug event predictions

J Rebane, I Samsten, P Pantelidis… - 2021 IEEE 34th …, 2021 - ieeexplore.ieee.org
Attention mechanisms form the basis of providing temporal explanations for a variety of state-
of-the-art recurrent neural network (RNN) based architectures. However, evidence is lacking …

A classification framework for exploiting sparse multi-variate temporal features with application to adverse drug event detection in medical records

F Bagattini, I Karlsson, J Rebane… - BMC medical informatics …, 2019 - Springer
Abstract Background Adverse drug events (ADEs) as well as other preventable adverse
events in the hospital setting incur a yearly monetary cost of approximately $3.5 billion, in …

ADENet: a novel network-based inference method for prediction of drug adverse events

Z Yu, Z Wu, W Li, G Liu, Y Tang - Briefings in Bioinformatics, 2022 - academic.oup.com
Identification of adverse drug events (ADEs) is crucial to reduce human health risks and
improve drug safety assessment. With an increasing number of biological and medical data …

Cascading adverse drug event detection in electronic health records

J Zhao, A Henriksson, H Boström - 2015 IEEE International …, 2015 - ieeexplore.ieee.org
The ability to detect adverse drug events (ADEs) in electronic health records (EHRs) is
useful in many medical applications, such as alerting systems that indicate when an ADE …

Machine learning-based methods and novel data models to predict adverse drug reaction

J Wang, Y Deng, L Shu, L Deng - 2020 IEEE International …, 2020 - ieeexplore.ieee.org
Predicting adverse drug reactions (ADRs) plays a critical role in developing new drugs and
preventing adverse reactions during the treatment of existing drugs. However, with the rapid …