Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal tract. At the molecular level, GISTs can be categorized into two groups …

Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important
contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory …

Recombinant strains of hepatitis E virus (HEV) with insertions of human genomic fragments
or HEV sequence duplications in the sequence encoding the polyproline region (PPR) were …

CREB-binding protein (CBP) participates in numerous transcription events. However, cell-
intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts …

Natural products derived from microorganisms play a key role in the discovery and
development of drug candidates. Several drugs have originated from secondary metabolites …

Cell-free protein synthesis (CFPS) has emerged as a novel protein expression platform.
Especially the incorporation of non-canonical amino acids (ncAAs) has led to the …

Inflammation has a central role in the etiology of type 2 diabetes (T2D) and its complications.
Both genetic and epigenetic factors have been implicated in the development of T2D …

The valuable bioactive compounds produced by endophytic fungi hold huge potential, which
may be utilized by pharmaceutical, agriculture or food industries. However, it has been …

Congenital heart disease (CHD) is a group of anatomic malformations in the heart with high
morbidity and mortality. The mammalian heart is a complex organ, the formation and …

Ribosomal DNA (rDNA) transcription drives cell growth and cell proliferation via the product
ribosomal RNA (rRNA), the essential component of ribosome. Given the fundamental role of …