Weaver syndrome (WS), an overgrowth/intellectual disability syndrome (OGID), is caused by
pathogenic variants in the histone methyltransferase EZH2, which encodes a core …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …

Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

All mammals progress through similar physiological stages throughout life, from early
development to puberty, aging, and death. Yet, the extent to which this conserved …

Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

The formation and maintenance of the epidermis depend on epidermal stem cell
differentiation and must be tightly regulated. Epigenetic mechanisms such as DNA …

Abstract Changes in DNA methylation at specific CpG sites have been used to build
predictive models to estimate animal age, predominantly in mammals. Little testing for this …

Funded by the European Commission Horizon 2020 programme, the Lifepath research
consortium aimed to investigate the effects of socioeconomic inequalities on the biology of …

Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …