Background Children of aged fathers are at a higher risk of developing mental disorders.
Alterations in sperm DNA methylation have been implicated as a potential cause. However …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

Aging is a multifactorial process, which affects the human body on every level and results in
both biological and psychological changes. Multiple studies have demonstrated that a lower …

Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Background: The blood metabolome incorporates cues from the environment and the host's
genetic background, potentially offering a holistic view of an individual's health status …

Background Chronological age is a prominent risk factor for many types of cancers including
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …

Robust biomarkers of aging have been developed from DNA methylation in humans and
more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a …

Background Epigenetic mechanisms may partly explain the persistent effects of adverse
childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict …

Background Schizophrenia (SZ) is associated with increased all-cause mortality, smoking,
and age-associated proteins, yet multiple previous studies found no association between SZ …

Highly reproducible smoking-associated DNA methylation changes in whole blood have
been reported by many Epigenome-Wide-Association Studies (EWAS). These epigenetic …