Identifying the molecular programs underlying human organ development and how they
differ from model species is key for understanding human health and disease …

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental
changes in the early embryo. PSCs can be stabilized in the naive state by blocking …

tRNA-derived small RNAs (tsRNAs) from spermatozoa could act as acquired epigenetic
factors and contribute to offspring phenotypes. However, the roles of specific tsRNAs in early …

Background Many studies have demonstrated the benefits of the addition of growth hormone
(GH) to the controlled ovarian stimulation protocol in vitro fertilization (IVF) cycles in poor …

Maternal mRNA degradation is a critical event of the maternal‐to‐zygotic transition (MZT)
that determines the developmental potential of early embryos. Nuclear Poly (A)‐binding …

Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are
essential for folliculogenesis. Pathological changes in GCs are found in several ovarian …

After fertilization, mouse embryos go through preimplantation development to give rise to
blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell …

Single-cell sequencing (SCS) is a next-generation sequencing method that is mainly used to
analyze differences in genetic and protein information between cells, to obtain genetic …

The study on the safety of nanomaterials in eyes is still in its early stages. In this study, we
put our focus on the effect of one important nanoparticle feature–large surface area–to …

We consider the scientific evidence that research on in-vitro development of embryos
beyond 14 days is necessary. We then examine potential new developments in the use of …