Early embryonic development is characterized by drastic changes in chromatin structure that
affects the accessibility of the chromatin. In human, the chromosome reorganization and its …

It is necessary to compare the transcriptomic profiles of human embryos cultured in time-
lapse imaging (TLI) incubators and standard incubators (SI) in order to determine whether a …

Single-cell RNA-seq has been established as a reliable and accessible technique enabling
new types of analyses, such as identifying cell types and studying spatial and temporal gene …

After fertilization, highly differentiated sperm and oocyte are reprogrammed to totipotent
embryo, which subsequently cleavages and develops into an individual through spatial …

Background In recent years, the rapid development of single-cell RNA-sequencing (scRNA-
seq) techniques enables the quantitative characterization of cell types at a single-cell …

In the twentieth century, many researchers have started working on bioinformatics for
disease biomarker detection using genetic information, ie, DNA microarray dataset and RNA …

Background During mammalian early embryogenesis, expression and epigenetic
heterogeneity emerge before the first cell fate determination, but the programs causing such …

Genomes are characterized by large regions of homogeneous base compositions known as
isochores. The latter are divided into GC-poor and GC-rich classes linked to distinct …

The comprehensive understanding of early embryo development is essential to optimize in
vitro culture conditions. Protein expression landscape of parthenogenetically produced …

The perturbed genes from transcriptomes are often presented in terms of relative
expressions against control samples. However, the probe signal values (PSVs) of genes …