For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Aging is a major risk factor for numerous human pathologies, including cardiovascular,
metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies …

Pharmacologically active compounds with preferential cytotoxic activity for senescent cells,
known as senolytics, can ameliorate or even revert pathological manifestations of …

Although cellular senescence acts primarily as a tumour suppression mechanism, the
accumulation of senescent cells in vivo eventually exerts deleterious side effects through …

The crosstalk between deregulated hepatocyte metabolism and cells within the tumour
microenvironment, as well as the consequent effects on liver tumorigenesis, are not …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …

To understand the role of the extensive senescence-associated 3D genome reorganization,
we generated genome-wide chromatin interaction maps, epigenome, replication-timing …