R De Gregorio, X Chen, EI Petit, K Dobrenis… - Cerebral …, 2020 - academic.oup.com
In mice, terminal differentiation of subpopulations of interneurons occurs in late postnatal stages, paralleling the emergence of the adult cortical architecture. Here, we investigated …
B Hu, H Won, W Mah, R Park, B Kassim, K Spiess… - bioRxiv, 2020 - biorxiv.org
Cellular heterogeneity in the human brain obscures the identification of robust cellular regulatory networks. We integrated genome-wide chromosome conformation in purified …
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism spectrum disorders (ASD) are genetically and phenotypically highly heterogeneous and …
D Trudler, S Ghatak, J Parker, M Talantova… - BioRxiv, 2020 - biorxiv.org
MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a …
N Wu, Y Wang, YH Pan, X Yuan - bioRxiv, 2020 - researchgate.net
Genetic variants of a large group of susceptibility genes have been associated with similar clinical manifestations of autism spectrum disorders (ASD), suggesting convergent function …
M Raygada, P Grant, OM Rennert - Personalized Psychiatry, 2020 - Elsevier
Autism spectrum disorder (ASD) is a panoply of different diseases that share a set of common behavioral traits, specifically social communication deficits, and repetitive and …
E Buglo - University of Miami, 2020 - scholarship.miami.edu
Rare hereditary neurodegenerative diseases are a group of genetic Mendelian disorders afflicting the central and/or peripheral nervous system. On one hand, these diseases are …
Recent exome-sequencing studies on patients with (nonsyndromic) autism and their parents have identified the first tens of genes that, if mutated, likely contribute to the autism …