[HTML][HTML] Emerging concepts and technologies in vaccine development

M Brisse, SM Vrba, N Kirk, Y Liang, H Ly - Frontiers in immunology, 2020 - frontiersin.org
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

[HTML][HTML] Toward precision adjuvants: optimizing science and safety

E Nanishi, DJ Dowling, O Levy - Current opinion in pediatrics, 2020 - journals.lww.com
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …

[HTML][HTML] Why and how vaccines work

A Iwasaki, SB Omer - Cell, 2020 - cell.com
Why and How Vaccines Work: Cell Skip to Main Content Advertisement Cell This journal offers
authors two options (open access or subscription) to publish research Submit Log in Register …

Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination

TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

[HTML][HTML] Host-malaria parasite interactions and impacts on mutual evolution

X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

DK Raj, A Das Mohapatra, A Jnawali, J Zuromski… - Nature, 2020 - nature.com
Malaria caused by Plasmodium falciparum remains the leading single-agent cause of
mortality in children, yet the promise of an effective vaccine has not been fulfilled. Here …

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

R Murugan, SW Scally, G Costa, G Mustafa, E Thai… - Nature medicine, 2020 - nature.com
The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …

[HTML][HTML] Challenges of developing novel vaccines with particular global health importance

PM Heaton - Frontiers in immunology, 2020 - frontiersin.org
Six of the top ten leading causes of death in low resource settings could potentially be
prevented by vaccination. Development of vaccines for individuals in these populations is …

[HTML][HTML] Plasmodium falciparum pre-erythrocytic stage vaccine development

J Molina-Franky, L Cuy-Chaparro, A Camargo… - Malaria journal, 2020 - Springer
Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites
(mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence …

Immune system development varies according to age, location, and anemia in African children

DL Hill, EJ Carr, T Rutishauser, G Moncunill… - Science translational …, 2020 - science.org
Children from low-and middle-income countries, where there is a high incidence of
infectious disease, have the greatest need for the protection afforded by vaccination, but …