Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Reversal of aging symptoms and related disorders are the challenging task where
epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

Epigenetic modifications like DNA methylation and histone acetylation play an important role
in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis …

It is becoming more evident that histone acetylation, as one of the epigenetic modifications
or markers, plays a key role in the etiology of Alzheimer's disease (AD). Histone acetylases …

Neurodegenerative disease strikes millions worldwide and there is mounting evidence
suggesting that underlying the onset and progression of these debilitating diseases is …

INTRODUCTION: Epigenetic modifications, such as histone acetylation and deacetylation,
are responsible for maintaining chromatin stability. As such, they have been implicated in a …

Histone deacetylases (HDAC s) represent emerging therapeutic targets in the context of
neurodegeneration. Indeed, pharmacologic inhibition of HDAC s activity in the nervous …