[HTML][HTML] Cellular mechanisms of human atherogenesis: focus on chronification of inflammation and mitochondrial mutations

AM Markin, IA Sobenin, AV Grechko, D Zhang… - Frontiers in …, 2020 - frontiersin.org
Atherosclerosis is one of the most common diseases of the cardiovascular system that leads
to the development of life-threatening conditions, such as heart attack and stroke …

Mitochondrial mutations in atherosclerosis: new solutions in research and possible clinical applications

IA Sobenin, DA Chistiakov… - Current …, 2013 - ingentaconnect.com
Cardiovascular diseases are the leading causes of morbidity and mortality in many
industrialized societies. Atherosclerosis is the major risk factor for the development of …

Mitochondrion as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
Background: Atherosclerosis is a chronic inflammatory condition that affects different arteries
in the human body and often leads to severe neurological complications, such as stroke and …

[HTML][HTML] Atherosclerosis as mitochondriopathy: Repositioning the disease to help finding new therapies

T Shemiakova, E Ivanova, WK Wu… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex pathology that involves both metabolic dysfunction and chronic
inflammatory process. During the last decade, a considerable progress was achieved in …

Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
Atherosclerosis is a multifactorial disease of the cardiovascular system associated with
aging, inflammation, and oxidative stress. An important role in the development of …

Changes in mitochondrial genome associated with predisposition to atherosclerosis and related disease

A Volobueva, A Grechko, SF Yet, I Sobenin, A Orekhov - Biomolecules, 2019 - mdpi.com
Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and
mortality, and the search for novel diagnostic and therapeutic methods is ongoing …

Possible role of mitochondrial DNA mutations in chronification of inflammation: focus on atherosclerosis

AN Orekhov, NN Nikiforov, EA Ivanova… - Journal of clinical …, 2020 - mdpi.com
Chronification of inflammation is the process that lies at the basis of several human diseases
that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of …

Changes of mitochondria in atherosclerosis: possible determinant in the pathogenesis of the disease

IA Sobenin, MA Sazonova, AY Postnov, YV Bobryshev… - Atherosclerosis, 2013 - Elsevier
Electron-microscopic analysis of atherosclerotic lesions demonstrated a high variability in
the ultrastructural appearance of mitochondria in human aortic atherosclerotic lesions …

Mutations of mitochondrial DNA in atherosclerosis and atherosclerosis-related diseases

IA Sobenin, AV Zhelankin… - Current …, 2015 - ingentaconnect.com
Atherosclerosis, the primary cause of cardiovascular disease, is a complex and multifactorial
pathology resulted from the harmful interactions between genetic and environmental factors …