The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly
expanding the known proteome at the lower end of the size distribution. Here, we show that …

In order to combat molecular damage, most cellular proteins undergo rapid turnover. We
have previously identified large nuclear protein assemblies that can persist for years in post …

Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …

Mitochondria exert an immense amount of cytophysiological functions, but the structural
basis of most of these processes is still poorly understood. Here we use cross-linking mass …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Mitochondrial respiratory complex subunits assemble in supercomplexes. Studies of
supercomplexes have typically relied upon antibody-based quantification, often limited to a …

Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts
in recent decades have established the core protein componentry of these organelles and …

Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently
demonstrated the translation of alternative open-reading frames (altORFs) in addition to …

Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …