Differential inhibition of gelatinase activity in human colon adenocarcinoma cells by Aloe vera and Aloe arborescens extracts

A Lima, P Batista-Santos, E Veríssimo… - … Medicine and Therapies, 2020 - Springer
Background Aloe's reported bioactivities (anticancer, anti-inflammatory and wound healing)
suggest they might inhibit a subgroup of matrix metalloproteinases (MMPs) called …

Inhibition of metalloproteinases by Aloe vera, Annona muricata, and black tea aqueous extracts.

RIMA Ribeiro, JS Kuribayashi, PC Borges Junior… - 2010 - cabidigitallibrary.org
Matrix metalloproteinases may exert important roles in both physiologic and pathologic
extracellular matrix remodeling. They have been implicated in tumoral progression of many …

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB

P Suboj, S Babykutty, DRV Gopi, RS Nair… - European journal of …, 2012 - Elsevier
Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in
various cancer cell lines. In this study we analyzed molecular mechanisms involved in the …

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

JM Macharia, V Ngure, B Emődy, B Kiraly, Z Kaposztas… - Pharmaceutics, 2023 - mdpi.com
Aloe species are widespread and diverse in African ecosystems, and this commonly
correlates to their habitual use as reservoirs of herbal medicine. The side effects associated …

Down‐regulation of MMP‐2 through the p38 MAPK‐NF‐κB‐dependent pathway by aloe‐emodin leads to inhibition of nasopharyngeal carcinoma cell invasion

ML Lin, YC Lu, JG Chung, SG Wang… - Molecular …, 2010 - Wiley Online Library
Abstract Aloe‐emodin (AE), extracted from the rhizome of Rheum palmatum, has an anti‐
proliferative effect on different human cancer cell lines. Nonetheless, the underlying …

Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells

J Guo, B Xiao, Q Liu, Z Gong, Y Le - Cancer investigation, 2008 - Taylor & Francis
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera, as well as in leaves and roots of
other plants. The mechanisms of its anticancer effect are largely unknown. The present study …

Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin

J Guo, B Xiao, S Zhang, D Liu, Y Liao… - Cancer biology & …, 2007 - Taylor & Francis
Aloe-emodin is a novel active compound found in the root and rhizome of Rheum palmatum.
To investigate the effects and mechanisms of aloe-emodin on human gastric cancer, MGC …

Inhibitory effect of aloe-emodin on metastasis potential in HO-8910PM cell line

TP He, WH Yan, LE Mo, NC Liang - Journal of Asian natural …, 2008 - Taylor & Francis
Aloe-emodin (AE) has been demonstrated to have antitumor activity in several tumor cells.
However, no information is available on the effect of AE on metastasis in human carcinoma …

Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells

B Xiao, J Guo, D Liu, S Zhang - Oral oncology, 2007 - Elsevier
Aloe-emodin is a natural anthraquinone compound from the root and rhizome of Rheum
palmatum. In this study, KB cells were treated with 2.5, 5, 10, 20, and 40μM aloe-emodin for …

[PDF][PDF] Antioxidant and antiproliferative activities of methanolic extract of Aloe vera leaves in human cancer cell lines

S Masaldan, VV Iyer - J. Pharm. Res, 2011 - Citeseer
The aims of this study were to investigate the antioxidant (radical scavenging, reducing) and
antiproliferative potential of a methanolic extract (ME) of Aloe vera leaves. DPPH radical …