Aim To conduct a comprehensive review of studies of glycaemic deterioration in type 2
diabetes and identify the major factors influencing progression. Methods We conducted a …

OBJECTIVE To identify the clinical and genetic factors that explain why the rate of diabetes
progression is highly variable between idividuals following diagnosis of type 2 diabetes …

Introduction: The risk for diabetes progression varies greatly in individuals with type 2
diabetes mellitus (T2DM). We aimed to study the clinical determinants of diabetes …

OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2
diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed …

Background Type 2 diabetes (T2D) is a progressive disease whereby there is often
deterioration in glucose control despite escalation in treatment. There is significant …

The prevalence of type 2 diabetes mellitus is increasing dramatically across most regions of
the world in children, adolescents, and young adults. The overall prevalence of type 2 …

Aims Both lifestyle factors and genetic background contribute to the development of type 2
diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not …

Background Type 2 diabetes mellitus is thought to develop from an interaction between
environmental and genetic factors. We examined whether clinical or genetic factors or both …

Aims/hypothesis There is considerable variability in how diabetes progresses after
diagnosis. Progression modelling has largely focused on 'time to failure'methods, yet …

More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test
whether a genetic risk score associates with the incidence of type 2 diabetes and with 5-year …