Acute kidney injury is a major contributor of chronic kidney disease development. The
pathogenesis of acute kidney injury and chronic kidney disease shows significant …

Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the
global population. Kidney disease encompasses a diverse group of disorders that vary in …

Hypoxia plays a role in ischemic, toxic and sepsis-induced acute kidney injury. Evolving
hypoxia triggers renal adaptive responses that may mitigate the insult, leading to sublethal …

AKI is a frequent condition that involves renal microcirculation impairment, infiltration of
inflammatory cells with local production of proinflammatory cytokines, and subsequent …

The innate immune system has been implicated in both AKI and CKD. Damaged
mitochondria release danger molecules, such as reactive oxygen species, DNA, and …

Mitochondrial dysfunction within the tubular epithelium has been implicated in the
pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate …

Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

Insights into the relationship between immunometabolism and inflammation have enabled
the targeting of several immunity-mediated inflammatory processes that underlie infectious …

Sepsis-associated acute kidney injury (AKI) is a common and morbid condition that is
distinguishable from typical ischemic renal injury by its paucity of tubular cell death. The …